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Clarithromycin, the active substance of Clarem, belongs to the group of antibiotics called macrolides. It is used in the treatment of bacterial infections appearing in various parts of our body. By its action Clarithromycin kills the microbes or inhibits their development. It should not be administered in the common cold, influenza or other infections caused by viruses

Active substance: Clarithromycin Excipients: Microcrystalline Cellulose, Sodium Starch Glycollate, Colloidal Silicon Dioxide, Magnesium Stearate, Hypromellose, Macrogol 400, Titanium Dioxide, Talc, Quinoline Yellow E104, Orange flavour, Povidone.

Clarithromycin, the active substance of Clarem, belongs to the group of antibiotics called macrolides. It is used in the treatment of bacterial infections appearing in various parts of our body. By its action Clarithromycin kills the microbes or inhibits their development. It should not be administered in the common cold, influenza or other infections caused by viruses. Indications: Clarem is indicated for the treatment of infections caused by strains of susceptible bacteria. Respiratory tract infections: acute and chronic bronchitis, pneumonia, sinusitis and pharyngitis. Skin and soft tissue infections of mild to moderate severity. Clarem is also indicated for the eradication of the helicobacter pylori in patients with duodenal ulcer.

As with all medicines Clarem may cause undesirable effects. Most usual are: Nausea, vomiting, dyspepsia, intestinal upsets, diarrhoea, urticaria, rashes and other allergic reactions, loss of hearing following large doses which is reversible on withdrawal of the drug, cholestatic jaundice, hepatitis, headache, disorders in the sense of smell and taste, discolouration of teeth and tongue, stomatitis, glossitis, arthralgia, myalgia, dizziness, vertigo, tinnitus, agitation, insomnia, nightmares, confusion, psychosis, hypoglycaemia, StevensJohnson syndrome, tachycardia. If you experience undesirable effects not mentioned above, please contact your doctor

A number of medicines interact with Clarithromycin and should not be used concomitantly with clarithromycin. However, a few of them can be used concomitantly under special precautions. In this case, your doctor can change the posology or take other precautions if needed. If you are about to take Clarithromycin it is important to inform your doctor or pharmacist if you are taking any other medications and in particular any of the following:  Theophylline, carbamazepine, midazolam, triazolam, alprazolam, sildenafil, quinidine, tacrolimus, warfarin, digoxin, ergotamine or dihydroergotamine, phenytoin, disopyramide, symvastatin or lovastatin, cyclosporine, zidovudine, rifabutin, ritonavir, ranitidine, colchicine, omeprazole, Maalox.

In case you have taken a dose larger than normal, contact your doctor immediately.  Overdosage symptoms: gastro-intestinal symptoms and rarely altered mental status, paranoid behaviour, hypokalemia and hypoxemia.  Adverse reactions accompanying overdosage should be treated by gastric lavage and supportive measures.

Follow your doctor’s instructions. Respiratory, skin and soft tissue infections: Adults: 250mg twice daily for 7 days. The dose may be increased to 500mg twice daily for up to 14 days in severe infections. Children over 12 years old: Same as adults H. pylori-associated infection with duodenal ulcer (Adults): Triple therapy (7-14 days) 500mg clarithromycin twice daily with lansoprazole 30mg twice daily should be given with 1000mg amoxicillin twice daily for 7 - 14 days. Triple therapy(7 days) 500mg clarithromycin twice daily with lansoprazole 30mg twice daily should be given with metronidazole 400mg twice daily for 7 days. Triple therapy(7 days) 500mg twice daily and omeprazole 40mg daily should be given with 1000mg amoxicillin twice daily for 7 days Triple therapy(10 days) 500mg clarithromycin twice daily should be given with 1000mg amoxicillin twice daily and omeprazole 20mg daily for 10 days. Dual therapy(14 days) 500mg clarithromycin 3 times daily for 14 days. Clarem should be administered with omeprazole 40mg once daily for 28 days. Elderly: As for adults Renal impairment: 250mg once daily or 250mg twice daily in more severe infections. Clarem can be taken either with or without food

Product expiry date Shown on the inner and outer packaging. In case the expiry date has lapsed, do not use. Special precautions for storage of the product: It is stored below 25OC, away from light and moisture and in a safe place out of the reach of children.